Understanding Substance P: How Pain Signals Work & A Natural Way to Calm Them

Substance P is a neuropeptide that plays a key role in transmitting pain signals throughout the body. When your body experiences injury, irritation, or inflammation, Substance P is released from nerve endings.

Once released, it binds to specialized receptors in the spinal cord and brain—triggering a chain reaction that sends pain messages through the central nervous system. The more Substance P is released, the stronger the pain signal.

This discovery has led researchers to explore Substance P’s role in chronic pain, inflammation, migraines, arthritis, and nerve discomfort.

Why Pain Is Complex

Pain isn’t a simple sensation—it’s influenced by inflammation levels, past injuries, stress, activity, age, and more. Because pain varies from person to person, a flexible, natural approach to management often works best.

Plant-based compounds—especially capsaicin from cayenne—help reduce Substance P activity over time and break the cycle of recurring pain.

A Natural Solution Designed to Calm Pain at the Source

Elly’s Joint & Muscle Pain Relief Rub uses a synergistic blend of plant-based ingredients designed to soothe discomfort and improve circulation. Cayenne (capsaicin) helps naturally reduce Substance P in targeted areas—helping quiet pain signals at the source.

Key Natural Ingredients:

• Cayenne (Capsaicin) – helps reduce Substance P activity
• CBD – supports inflammation reduction and relaxation
• Arnica – eases soreness, stiffness, and swelling
• Menthol & Wintergreen – cooling relief that reduces tension
• Plant Oils & Butters – nourish and hydrate the skin

Why People Love Topical Pain Relief

• Targets discomfort exactly where it occurs
• Avoids the stomach or organ side effects of oral meds
• Can be used multiple times a day as needed
• Excellent for chronic muscle, joint, or nerve pain
• Supports mobility, flexibility, and comfort

A Relief Option Your Body Will Appreciate

If you're looking for a safe, effective alternative to traditional pain relievers, Elly’s Joint & Muscle Pain Relief Rub offers natural comfort without harsh chemicals or side effects.